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You are here: Home Administration Chemistry & Biochemistry Department Events 2018 February Biochemistry Seminar: Philip A. Cole, "Mechanistic Insights into PTEN Regulation"

Biochemistry Seminar: Philip A. Cole, "Mechanistic Insights into PTEN Regulation"

Philip A. Cole, Professor, Dept of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, MA, "Mechanistic Insights into PTEN Regulation"
When Feb 14, 2018
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

The lipid phosphatase PTEN is a key tumor suppressor gene that regulates the level of the phospholipid PIP3 in cells, opposing the action of PI3-kinase.  Rising PIP3 promotes cancer cell growth by stimulating Akt protein kinase activity.  PTEN function is modulated by phosphorylation and the ubiquitin ligase WWP2.  We will discuss our progress on understanding the mechanisms of regulation of PTEN, WWP2, and Akt by intramolecular interactions and post-translational modifications and how these findings may inform the development of anti-cancer strategies.

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