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Biochemistry Seminar: Bridget Carragher and Clint Potter, "CryoEM: Challenges and Opportunities"

Bridget Carragher and Clint Potter, Directors, Simons Electron Microscopy Center, New York Structural Biology Center, "CryoEM: Challenges and Opportunities"
When Apr 11, 2018
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

In the last five years we have witnessed dramatic improvements in the progress of single particle cryo electron microscopy (cryoEM).  New detectors and image processing software have enabled reconstruction of atomic resolution maps, at least for large well ordered macromolecules.  High levels of automation in image acquisition and processing have enabled the reconstruction of multiple different states of molecular machines from a single sample.  This provides the opportunity to understand structures that may be highly heterogeneous and/or dynamic.   A brief overview of some of the new technologies will be presented, the power of the method will be illustrated by its application to the understanding of dynamic molecular machines, and a view of the anticipated future advances will be discussed.

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