Personal tools
You are here: Home Administration Chemistry & Biochemistry Department Events 2018 September Biochemistry Seminar: E. James Petersson, "Studing Parkinson's Disease with Semi-Synthetic Proteins"

Biochemistry Seminar: E. James Petersson, "Studing Parkinson's Disease with Semi-Synthetic Proteins"

E. James Petersson, Associate Professor, Department of Chemistry, Perelman School of Medicine, University of Pennsylvania, PA, "Studying Parkinson's Disease with Semi-Synthetic Proteins"
When Sep 05, 2018
from 12:00 PM to 01:00 PM
Where CUNY ASRC 5th Floor Data Visualization Room
Contact Name
Contact Phone 212-650-8803
Add event to calendar vCal
iCal

ABSTRACT

Our laboratory develops new methods to study the misfolding of amyloidogenic proteins, including α-synuclein, which has been implicated in the pathogenesis of Parkinson’s Disease.  We utilize unnatural amino acid mutagenesis, bioorthogonal labeling techniques, and protein ligation to produce homogenous α-synuclein labeled with fluorescent probes.  Fluorescence measurements are used to generate models of misfolded forms of α-synuclein.  These models allow us to identify small molecules that bind to α-synuclein to prevent the formation of amyloid fibrils or to be used as imaging agents for the early identification of Parkinson’s Disease pathology.  We have also used fluorescently labeled α-synuclein to understand the mechanism of amyloid spread between neurons, which has the potential to identify new drug targets.  Taken together, our studies provide insight into the mechanism of α-synuclein toxicity in Parkinson’s Disease as well as the development of potential treatments.

More information about this event…