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You are here: Home Administration Chemistry & Biochemistry Department Events 2018 September Biochemistry Seminar: Sanford Simon, "The Dynamics of ESCRT Proteins in the Cell: Lessons from Studying Single Virions of HIV-1"

Biochemistry Seminar: Sanford Simon, "The Dynamics of ESCRT Proteins in the Cell: Lessons from Studying Single Virions of HIV-1"

Sanford Simon, Professor, Biophysics, Chemical Biology & Structural Biology, Rockefeller University, NY, "The Dynamics of ESCRT Proteins in the Cell: Lessons from Studying Single Virions of HIV-1"
When Sep 26, 2018
from 12:00 PM to 01:00 PM
Where CUNY ASRC 5th Floor Data Visualization Room
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

A critical step in the HIV life cycle is the generation of an enveloped virus. Viral-encoded proteins including the structural protein Gag assemble at the plasma membrane where scission is facilitated by members of the Endosomal Sorting Complex Required for Transport (ESCRT) protein family. From studying the assembly of single virions of HIV-1 at a time, we characterized the dynamics of formation of the Gag lattice and timing of recruitment of the genome and host factors, such as the ESCRTs relative to membrane scission.

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