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You are here: Home Administration Chemistry & Biochemistry Department Events 2018 December Biochemistry Seminar: Alan D. Grossman, "Horizontal Gene Transfer: Control and Visualization of Bacterial Sex"

Biochemistry Seminar: Alan D. Grossman, "Horizontal Gene Transfer: Control and Visualization of Bacterial Sex"

Alan D. Grossman, Professor and Head, Department of Biology, Massachusetts Institute of Technology, MA, "Horizontal Gene Transfer: Control and Visualization of Bacterial Sex"
When Dec 05, 2018
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

Horizontal gene transfer plays a major role in microbial evolution and genome plasticity, allowing microbes to acquire new genes and phenotypes. Conjugation, or bacterial sex, is mediated by two types of conjugative elements: conjugative plasmids (e.g., F in E. coli) and conjugative transposons, also known as integrative and conjugative elements (ICEs). ICEs typically have genes directly involved in the ICE lifecycle and so-called 'cargo' genes that can be of benefit to the host. ICEs are known to be involved in the transfer of cargo genes for: antibiotic resistances, pathogenesis, symbiosis, and various metabolic functions. Our focus is primarily on understanding the life-cycle of ICEBs1, an integrative and conjugative element in Bacillus subtilis.  We study basic aspects of conjugation and regulation that are widely conserved in other conjugative elements, but that are not well understood. The seminar will focus on the ICE life cycle and insights from studying the biology of ICEBs1.

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