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You are here: Home Administration Chemistry & Biochemistry Department Events 2019 February Biochemistry Seminar: Gregory M. Alushin, "A mechanism of cellular force sensing through actin filaments"

Biochemistry Seminar: Gregory M. Alushin, "A mechanism of cellular force sensing through actin filaments"

Gregory M. Alushin, Assistant Professor Biochemistry, Biophysics, Chemical Biology, and Structural Biology, Rockefeller University, NY, "A mechanism of cellular force sensing through actin filaments"
When Feb 20, 2019
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

Mechanical forces can modulate the structures of macromolecules to regulate their activity (“mechanoregulation”), which underlies signal transduction pathways that enable cells to perceive mechanical cues in their environments (“mechanotransduction”). Mechanotransduction is critical for development and its dysregulation contributes to carcinogenesis and cancer metastasis, yet the mechanisms for transducing mechanical cues into modulation of gene expression remain poorly understood. We are currently investigating mechanoregulation of the cytoskeleton, the network of protein filaments, motor proteins, and associated binding partners (ABPs) which collectively orchestrate cell mechanics and coordinate mechanotransduction.  I will discuss our recent progress in directly visualizing mechanoregulation of the actin cytoskeleton using cryo-electron microscopy (cryo-EM), including identification of a force-induced conformation which may act as an upstream cue to regulate gene expression.

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