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You are here: Home Administration Chemistry & Biochemistry Department Events 2019 February Biochemistry Seminar: Jun Liu, "High throughput cryo-electron tomography: Visualizing molecular machines in cells at high resolution"

Biochemistry Seminar: Jun Liu, "High throughput cryo-electron tomography: Visualizing molecular machines in cells at high resolution"

Jun Liu, Associate Professor of Microbial Pathogenesis, Yale University School of Medicine, CT, "High throughput cryo-electron tomography: Visualizing molecular machines in cells at high resolution"
When Mar 20, 2019
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

Cryo-electron tomography (cryo-ET) has emerged as the method of choice to bridge the informational gap between light microscopy and atomic structure determinations, enabling visualization of molecules and organelles in their native cellular landscapes at molecular resolution.  My laboratory is dedicated to developing high-throughput cryo-ET pipelines in which both data collection and image analysis are streamlined and automated. Fueled by recent breakthroughs in both hardware and software that transformed cryo-EM, our high-throughput cryo-ET pipeline has become increasingly powerful, enabling us to visualize molecular machines in their native cellular context at resolutions not possible by any other technique. Here, I will present in situ structural information that has been systematically utilized to gain novel insights into flagellar assembly, protein secretion, and host-pathogen interactions.

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