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Biochemistry Seminar: Daniel Kahne, "Molecular Machines that Make Membranes"

Daniel Kahne, Higgins Professor of Chemistry and Chemical Biology, Harvard University, MA, "Molecular Machines that Make Membranes"
When Apr 03, 2019
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

The Kahne Lab is interested in understanding the biogenesis of the cell envelope of Gram-negative bacteria, in particular peptidoglycan biosynthesis and outer membrane assembly. The assembly of this membrane must be accomplished outside the cell in the absence of an obvious energy source. My research focuses on identifying and understanding the machinery necessary for proper assembly of this membrane barrier, as well as the mechanisms that lead to defects. Because the outer membrane creates an effective permeability barrier to most antibiotics, understanding how to interfere with its assembly could provide new targets for antibiotic discovery.

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