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You are here: Home Administration Chemistry & Biochemistry Department Events 2019 Fall Semester Biochemistry Seminar: Douglas Kojetin, "Ligand-induced structural dynamics and function of PPARγ learned through NMR"

Biochemistry Seminar: Douglas Kojetin, "Ligand-induced structural dynamics and function of PPARγ learned through NMR"

Douglas Kojetin, Associate Professor, Department of Integrative Structural and Computational Bio, Department of Molecular Therapeutics, Scripps Research, FL, "Ligand-induced structural dynamics and function of PPARγ learned through NMR"
When Nov 06, 2019
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

Structural studies of nuclear receptor transcription factors have revealed a conserved mechanism for agonist-induced coactivator interaction and transcriptional activation. In contrast, limited structural data indicate that ligand-induced corepressor-dependent nuclear receptor repression occurs through structurally diverse mechanisms. Furthermore, the conformational ensemble of the apo/ligand-free nuclear receptor ligand-binding domain, which is hypothesized to exchange between transcriptionally active and repressive conformations, remains poorly characterized. I will discuss our efforts to characterize how small molecule pharmacological ligands—agonists, antagonists, and inverse agonists—influence the conformational ensemble and function of the nuclear receptor PPARγ.

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