Personal tools
You are here: Home Administration Chemistry & Biochemistry Department Events 2019 Fall Semester Biochemistry Seminar: Kendra Frederick, "In-cell structural biology of proteins behaving badly"

Biochemistry Seminar: Kendra Frederick, "In-cell structural biology of proteins behaving badly"

Kendra Frederick, Assistant Professor, Department of Biophysics, Center for Alzheimer's and Neurodegenerative Diseases, Green Comprehensive Center for Molecular, Computational and Systems Biology, UT Southwestern Medical Center, "In-cell structural biology of proteins behaving badly"
When Dec 04, 2019
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
Add event to calendar vCal
iCal

ABSTRACT

The misfolded proteins associated with neurodegenerative disease can adopt a variety of different conformations, some of which are toxic. Because these proteins have identical amino acid sequences, the cellular environment clearly influences the final state, yet most structural studies do not include the cellular context and, perhaps because we are not studying the correct conformation, not a single therapeutic strategy for these diseases addresses the underlying protein misfolding pathology. Using new sensitivity-enhancement technology for solid state NMR spectroscopy, we study protein structure in native environments - inside living cells - to reveal how both healthy and disease-relevant cellular environments influence protein structure.

More information about this event…