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Biochemistry Seminar: Elizabeth Rhoades, "Functional mechanisms of dysfunctional proteins"

Elizabeth Rhoades, Associate Professor, Department of Chemistry, University of Pennsylvania, "Functional mechanisms of dysfunctional proteins"
When Mar 04, 2020
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression in Parkinson’s disease. I will describe our efforts to understand the role of neurexin 1β, a presynaptic cell adhesion glycoprotein, in cellular internalization of both monomer and aggregated αS. Our prior work found that extracellular N-linked glycoproteins, and neurexin 1β specifically, had a key role in neuronal uptake of αS. Using a variety of biophysical methods, we characterize the interactions of wild-type and Parkinson’s disease associated point variants of αS with neurexin 1β. Our work provides insight into molecular details of the interaction between αS and neurexin 1β and the resulting cellular internalization of αS.

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