Personal tools
You are here: Home Administration Chemistry & Biochemistry Department Events 2020 Spring Semester Biochemistry Seminar: Robert B. Best, "Structure and dynamics of intrinsically disordered proteins, their complexes and assemblies"

Biochemistry Seminar: Robert B. Best, "Structure and dynamics of intrinsically disordered proteins, their complexes and assemblies"

Robert B. Best, Senior Investigator: Theoretical Biophysical Chemistry Section, Laboratory of Chemical Physics, NIDDK, National Institutes of Health, "Structure and dynamics of intrinsically disordered proteins, their complexes and assemblies"
When Apr 01, 2020
from 12:00 PM to 01:00 PM
Contact Name
Contact Phone 212-650-8803
Add event to calendar vCal
iCal

 

This seminar will only be available remotely.
VIEW THIS SEMINAR LIVE VIA THE WEB AT:

https://zoom.us/j/449901184

 

ABSTRACT

Intrinsically disordered proteins are now realized to play a variety of important biological roles, yet pose a challenge for experiments, because observed signals are averaged over a very heterogeneous ensemble of structures. Molecular simulations can help to interpret the results, if appropriately parameterized to match experimental data. I will describe our work using both atomistic and coarse-grained simulations to model the structure and dynamics of disordered proteins, and their disordered complexes and assemblies, especially those involving highly charged biomolecules. These include the role of a protein chaperone in the folding of nucleic acids, and the formation of coacervates at lower ionic strength and higher protein concentrations.

More information about this event…