Personal tools
You are here: Home Administration Chemistry & Biochemistry Department Events 2021 Spring semester Biochemisry Seminar: Nicole A. LaRonde, "The intersection of the RIO kinases and PRMT5 in Ribosome Biogenesis"

Biochemisry Seminar: Nicole A. LaRonde, "The intersection of the RIO kinases and PRMT5 in Ribosome Biogenesis"

Nicole A. LaRonde, Associate Professor, Dept of Chemistry & Biochemistry, University of Maryland at College Park, will give a talk on "The intersection of the RIO kinases and PRMT5 in Ribosome Biogenesis."
When Feb 24, 2021
from 12:00 PM to 01:00 PM
Where Via Zoom
Contact Name
Contact Phone 212-650-8803
Add event to calendar vCal
iCal

ZOOM LINK:

https://gc-cuny-edu.zoom.us/j/88065912335

Meeting ID: 880 6591 2335

 

ABSTRACT

The RIO kinases are a unique group of protein kinases that are targets for anti-cancer drug discovery. They are essential ribosome biogenesis factors and contributors to several cancer signaling pathways. We have been using structural and biochemical characterization to understand the functions of these enzymes. As part of its role, RIOK1 interacts with PRMT5, an arginine methyltransferase also active in cancers. Together, these proteins cooperate to methylate nucleolin, a major component of the nucleolus where ribosomes are made, and a participant in ribosomal RNA transcription. We have studied these proteins via structural and biochemical methods and designed and synthesized small molecule inhibitors of RIOK1 that modulate its function. I will discuss what we have learned about the interactions of these proteins and the implications for targeting ribosome biogenesis for anti-cancer strategies.

More information about this event…