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You are here: Home Administration Chemistry & Biochemistry Department Events Archives 2018 October Biochemistry Seminar: Mirkó Palla, "High-Throughput Nanopore-Based Methods to Read DNA"

Biochemistry Seminar: Mirkó Palla, "High-Throughput Nanopore-Based Methods to Read DNA"

Mirkó Palla, Postdoctoral Research Fellow, Department of Genetics, Harvard Medical School, Wyss Institute for Biologically Inspired Engineering, MA, "High-Throughput Nanopore-Based Methods to Read DNA"
When Oct 03, 2018
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

Driven by the maturation of next-generation sequencing technologies, DNA sequencing has been dramatically expanding its scope in basic life science research and in clinical medicine. In this seminar, I will detail our recent study (Stranges* and Palla* et al., PNAS, 2016), in which we have provided proof-of-principle for a new integrated sequencing system that can lay the foundation for a highly scalable, accurate, single-molecule DNA sequencing platform. This has the potential to sequence entire genomes at much lower costs and to become instrumental for transforming many areas of precision medicine. I will then discuss an extension of this platform technology used as a multiplex screening tool for a library of DNA polymerases (in revision: Palla* and Punthambaker* et al., Nature Biotechnology, 2018) to identify variants with novel properties for applications of biotechnological interest.

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