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You are here: Home Administration Chemistry & Biochemistry Department Events June 2017 Seminar: Christian Griesinger, “Protein dynamics with applications in immunity, neurodegeneration and cancer”

Seminar: Christian Griesinger, “Protein dynamics with applications in immunity, neurodegeneration and cancer”

Christian Griesinger, Director and Scientific Member, Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute, will give a talk on "Protein dynamics with applications in immunity, neurodegeneration and cancer."
When Jun 19, 2017
from 12:00 PM to 01:00 PM
Where CUNY ASRC Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

The role of partially disordered proteins in two fields of research is investigated. One is the adaptor protein SLP65 which interacts with CIN85 (1). The two proteins are essential for B cell activation. The protein is found to be mainly unstructured and its various segments entertain different functions or interact with membranes, SH3 domains and forming coiled coils. Based on the structures, a molecular lego will be described that reduces the SLP65/CIN85 interaction to its absolutely necessary essentials. The two proteins can form supramolecular structures which might be related to function.

We are additionally interested in a class of IDPs that are important in neuro- and cellular degeneration, which form oligomers and fibrils. Interference with these aggregates specifically on the oligomer level proves to be a valid concept for treatment of devastating diseases such as Parkinson’s, Alzheimer’s, Creutzfeldt Jacob disease and Type II diabetes mellitus.