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You are here: Home Administration Chemistry & Biochemistry Department Events November 2017 Biochemistry Seminar: Andrew Jon Nieuwkoop, "Using Very Fast Spinning and Proton Detection to Solve Protein Structures with Solid State NMR"

Biochemistry Seminar: Andrew Jon Nieuwkoop, "Using Very Fast Spinning and Proton Detection to Solve Protein Structures with Solid State NMR"

Andrew Jon Nieuwkoop, Asst Prof, Chemistry & Chemical Biology, Rutgers University, NJ, "Using Very Fast Spinning and Proton Detection to Solve Protein Structures with Solid State NMR"
When Nov 29, 2017
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

Solid state NMR of biological systems is a rapidly expanding field that is tightly connected with improvements in hardware. The advantage of ssNMR as a technique is in its ability to address the structures of insoluble, noncrystallographic systems at atomic resolution. This is possible because of magic angle spinning, which averages anisotropic interactions leaving behind the sharp isotropic signals seen in solution NMR. In the last decade, the maximum MAS rates have increased first from 20 to 40 kHz, then to 60 kHz and very recently to 100+ kHz. As a result, new techniques have become available, one of which is proton detection.  I’ll discuss my work using proton detected ssNMR on membrane proteins. This will include optimization of pulse sequences and sample preparation, as well as computational improvements to aid in structure determination.

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