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You are here: Home Administration Chemistry & Biochemistry Department Events September 2017 Biochemistry Seminar: Chris Fromme, "How does the Golgi complex make decisions? A biochemical approach reveals extensive crosstalk between GTPase pathways"

Biochemistry Seminar: Chris Fromme, "How does the Golgi complex make decisions? A biochemical approach reveals extensive crosstalk between GTPase pathways"

Chris Fromme, Assoc. Prof, Dept. of Mol. Biology & Genetics, Weill Inst for Cell & Molecular Biology, Cornell University, Ithaca, NY, "How does the Golgi complex make decisions? A biochemical approach reveals extensive crosstalk between GTPase pathways"
When Sep 27, 2017
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

The Golgi complex is the primary sorting organelle at the nexus of the secretory and endocytic trafficking pathways. Once at the Golgi, proteins find themselves at a crossroads: they may be trafficked to the plasma membrane, to endocytic organelles, to lysosomal organelles, to the endoplasmic reticulum, or they may remain within the Golgi complex. The regulators for all incoming and outgoing Golgi traffic are GTPases of the Rab and Arf families. Arf and Rab proteins are activated by GEFs (guanine nucleotide exchange factors), which are the master regulators of these trafficking pathways. Despite knowing the identity of many of these regulators, the molecular and atomic basis for their regulation remains poorly defined. By investigating how the GEFs are regulated my lab aims to uncover the molecular logic governing regulation of the Golgi at a mechanistic level. We have found that Golgi trafficking is regulated through GEF autoinhibition, positive feedback, and GTPase crosstalk mechanisms. Specific protein-protein interactions and the lipid composition of the organelle membrane both play important roles in GEF localization and activity. Our findings indicate that the distinct trafficking pathways intersecting at the Golgi complex are sensed by one another.

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