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You are here: Home Administration Chemistry & Biochemistry Department Events September 2017 Biochemistry Seminar: Hashim M. Al-Hashimi, "Beyond Watson & Crick: Seeing the Invisible Genome"

Biochemistry Seminar: Hashim M. Al-Hashimi, "Beyond Watson & Crick: Seeing the Invisible Genome"

Hashim M. Al-Hashimi, Professor of Biochemistry, Director of the Duke Center for RNA Biology, Duke University School of Medicine, "Beyond Watson & Crick: Seeing the Invisible Genome"
When Sep 06, 2017
from 12:00 PM to 01:00 PM
Where CUNY ASRC Main Auditorium
Contact Name
Contact Phone 212-650-8803
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ABSTRACT

A key feature of the 3D genome that is taken for granted is that the double stranded DNA is composed of canonical G-C and A-T Watson-Crick base pairs. Our group made the discovery that in canonical DNA duplexes, Watson-Crick base pairs exist in dynamic equilibrium with non-canonical Hoogsteen base pairs in which the guanine or adenine base flips ~180 degrees to form a unique set of hydrogen bonds with its cytosine or thymine base complement. We are examining the enrichment of Hoogsteen base pairs relative to nucleosome positioning and other genomic features to assess potentially broader roles for Hoogsteen base pairs in genome accessibility, protein binding, and in shaping mutational and damage landscapes. Our group has also characterized an inverse process, in which mismatches transiently adopt a canonical Watson-Crick like geometry stabilized by rare tautomeric and anionic bases. These transitions acts as a molecular timer which clocks the frequency of errors during replication, transcription, and translation.

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