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Liquid Chromatography - Mass Spectrometry (LC-MS)

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General information about the facility.

  • Location: Marshak Science Building 1201, City Colleg of New York, 160 Convent Ave., New York, NY 10031
  • Staff:
    Dr. Lijia Yang: Phone:  (212) 650-6601, (212) 650-7774 (Lab)
    Dr. Pengfei Zhang: Phone: (212) 650-5609
    Dr. Urs Jans: Phone: (212) 650-8369

Fees

Please contact facility management for current fee schedule.

Facility Images

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Facility description


The 4000 Q TRAP™ LC/MS/MS System takes advantage of a number of mass spectrometry innovations to deliver unmatched quantitative and qualitative performance within a single system. The instrument combines the advanced features of Applied Biosystems/MDS SCIEX Linear Ion Trap (LIT) technology-including significantly higher injection and trapping efficiencies, greater ion capacity, and higher duty cycle—with the unequalled sensitivity of the leading triple quadrupole system.

The Waters Time-Of-Flight (TOF) Mass Spectrometer

The Waters time-of-flight (TOF) mass spectrometry facility in the Science Division of CCNY features an orthogonal acceleration time-of-flight (oa-TOF) mass analyzer, which provides an unique combination of speed, sensitivity, resolving power, dynamic range, and mass accuracy. It is ideal for both analysis and identification of molecules and ions in organic synthesis, pharmaceutical and biochemical study, and unknown compound discovery, which require exact mass measurement or high resolution mass spectroscopy (HRMS). It features:

  • Exact mass MS measurements: identify molecules using routine sub 3 ppm RMS mass measurements which give elemental composition information that can be used to identify analyte compounds;
  • High MS resolution: 12,000 FWHM which enables analyte peaks to be separated from interfering ions that might cause significant errors in exact mass determination
  • High sensitivity for achieving very low detection limits
  • High linear dynamic range, which allows experiments to be carried out across a range of concentration levels

 

Selected Publications Using Data from the CCNY Mass Spectrometry Facility

  • Mahesh K. Lakshman, Manish K. Singh, Mukesh Kumar, Raghu Ram Chamala, Vijayender R. Yedulla, Domenick Wagner, Evan Leung, Lijia Yang, Asha Matin and Sadia Ahmad. Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications. Beilstein J. Org. Chem. 2014, 10, 1919–1932.
  • Zhiwei Yin, Jinzhu Zhang, Jing Wu, Riana Green, Sihan Li and Shengping Zheng. Synthesis of o-chlorophenols via an unexpected nucleophilic chlorination of quinone monoketals mediated by N,N’-dimethylhydrazine dihydrochloride. Org. Biomol. Chem., 2014, 12, 2854.
  • Keyvan Dastmalchi, Qing Cai, Kevin Zhou, Wenlin Huang, Olga Serra, and Ruth E. Stark. Solving the Jigsaw Puzzle of Wound-Healing Potato Cultivars: Metabolite Profiling and Antioxidant Activity of Polar Extracts. J. Agric. Food Chem. 2014, 62, 7963−7975.
  • Chaoqi Chen, Jing Li, Peipei Chen, Rui Ding, Pengfei Zhang, Xiqing Li. Occurrence of antibiotics and antibiotic resistances in soils from wastewater irrigation areas in Beijing and Tianjin, China. Environmental Pollution 193 (2014) 94-101.
  • Zhiwei Yin, Jinzhu Zhang, Jing Wu, Che Liu, Kate Sioson, Matthew Devany, Chunhua Hu, and Shengping Zheng. Double Hetero-Michael Addition of N‑Substituted Hydroxylamines to Quinone Monoketals: Synthesis of Bridged Isoxazolidines. Org. Lett., Vol. 15, No. 14, 2013.
  • Mykola Seredych, Teresa J. Bandosz. Visible light photoactivity of sulfur and phosphorus doped nanoporous carbons in oxidation of dibenzothiophenes. Fuel 108 (2013) 846–849.
  • Dickens Saint-Hilaire, Urs Jans. Reactions of three halogenated organophosphorus flame retardants with reduced sulfur species. Chemosphere 93 (2013) 2033–2039.
  • Ravinder Kodela, Mitali Chattopadhyay, and Khosrow Kashfi. NOSH-Aspirin: A Novel Nitric Oxide−Hydrogen Sulfide-Releasing
    Hybrid: A New Class of Anti-inflammatory Pharmaceuticals. ACS Med. Chem. Lett. 2012, 3, 257−262.
  • Lijia Yang, Xiqing Li, Pengfei Zhang, Michael E. Melcer, Youxian Wu and Urs Jans. Concentrations of DDTs and dieldrin in Long Island Sound sediment. J. Environ. Monit., 2012, 14, 878–885.
  • Ka Wing Lo, Sumon C. Saha-Roy, Urs Jans. Investigation of the reaction of hexabromocyclododecane with polysulfide and bisulfide in methanol/water solutions. Chemosphere 87 (2012) 158–162.
  • Sherry Zhao, Pengfei Zhang, John Crusius, Kevin D. Kroegerc and John F. Bratton. Use of pharmaceuticals and pesticides to constrain nutrient sources in coastal groundwater of northwestern Long Island, New York, USA. J Environ Monit. 2011 May; 13(5):1337-43.

  • Dickens Saint-Hilaire, Kamal Z. Ismail, Urs Jans. Reaction of tris(2-chloroethyl)phosphate with reduced sulfur species. Chemosphere 83 (2011) 941–947.

  • Mykola Seredych, Monmon Khine, and Teresa J. Bandosz. Enhancement in Dibenzothiophene Reactive Adsorption from Liquid Fuel via Incorporation of Sulfur Heteroatoms into the Nanoporous Carbon Matrix. ChemSusChem 2011, 4, 139 – 147.

  • Mykola Seredych, Teresa J. Bandosz. Investigation of the enhancing effects of sulfur and/or oxygen functional groups of nanoporous carbons on adsorption of dibenzothiophenes. Carbon 49 2011 1216-1224.

  • Mykola Seredych and Teresa J. Bandosz. Adsorption of Dibenzothiophenes on Nanoporous Carbons: Identification of Specific Adsorption Sites Governing Capacity and Selectivity. Energy Fuels 2010, 24, 3352–3360.

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