Chemistry Seminar - Synthesis and Luminescence of Bis(di-tert-butylphenanthroline) Cu(I): a complex with unique reactivity and applications in solar cells
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Collin Yves Ewald
PhD Student
The City College of New YorkMarshek Building J-721
160 Convent Avenue
New York , NY 10031
Email:
cewald [ AT ] gc.cuny.edu
Work:
(212) 650-8533
Education:
- 2005 B.Sc., Molecular Biology, University of Basel, Switzerland
- 2007 M.Sc., Molecular Biology, University of Basel, Switzerland
- 2008 M.Phil., Biology, City University of New York
- 2006-present PhD candidate, Neuroscience, City University of New York
- PROFESSIONAL EXPERIENCE
- 2005-2006 Master’s research, Friedrich Miescher Institute, University of Basel. Laboratories of Dr. Joy Alcedo and Dr. Nancy Hynes
- 2006-2007 Teaching Assistant, Department of Biology, City College of New York
- 2006-present Research Assistant, Department of Biology, City College of New York
Biography:
Concentration: Neuroscience
Mentor: C. Li
RESEARCH
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder affecting over 12 million people worldwide. Post mortem autopsy of an AD patient’s brain reveals two characteristic features: senile plaques and neurofibrillary tangles. The senile plaques, which are unique to AD, consist of aggregated beta-amyloid peptide, which is derived from the amyloid precursor protein (APP). A small number of patients with familial Alzheimer’s disease have mutations in APP. Because of the difficulty of investigating the role of APP in mammals, we are using a simple model system, the worm C. elegans, to determine the role of APP-related proteins. The function of related proteins are generally conserved through evolution. In C. elegans, a single gene, apl-1, encodes a protein similar to human APP. Loss of apl-1 results in larval lethality, indicating that apl-1 plays an essential role in postembryonic development. This lethality can be rescued by microinjection of a wild-type copy of apl-1. By using transgenic strains that overexpress APL-1 in different cells of the animal, we can modify the lifespan of these animals. We are investigating the basis of the lifespan effects on apl-1 expression.
AWARD AND HONORS
2007 Doctoral Student Research Grant CUNY for 2008-09
2007 “2007 NYAS Future Entrepreneur” recognized by the New York Academy of Science
2008 CCNY GSC 2008 Graduate Student Award for best progress and productivity in the Neuroscience research program of the City University of New York.
2008 Sue Rosenberg Zalk Travel & Research Fund received for the traveling and presenting at European C. elegans Meeting 2008 in Spain.
PRESENTATIONS
2005 Collin Ewald et al.: Expression, Purification and NMR Spectroscopy of T-Cadherin Domain1. Biozentrum Switzerland (Poster)
2006 Collin Ewald, Nancy Hynes, Joy Alcedo: Characterization of the Worm Homolog of memo, a Gene that Acts Downstream of the Mammalian EGF Pathway. European Worm Meeting. (Poster)
2007 Collin Ewald and Chris Li: Does targeted overexpression of APL-1 in neurons extend lifespan? International Worm Meeting. (Poster)
2008 Collin Ewald and Chris Li: The role of APL-1, an amyloid precursor-like protein in C. elegans. European Worm Meeting. (Poster)
2008 Collin Ewald and Chris Li: The role of APL-1, an amyloid precursor-like protein in C. elegans. Ninth Annual Celebration of Science, Engineering and Mathematics. Graduate Center of the City University of New York. (Poster)
2008 Collin Ewald and Chris Li: How worms can provide insights into Alzheimer's disease. The Graduate Student Symposium at The City College of New York. (Poster)
2008 Collin Ewald and Chris Li: How worms can provide insights into Alzheimer's disease. Doctoral Science Student Orientation at The Graduate Center of the City University of New York. (Poster)
2007 Doctoral Student Research Grant CUNY for 2008-09
2007 “2007 NYAS Future Entrepreneur” recognized by the New York Academy of Science
2008 CCNY GSC 2008 Graduate Student Award for best progress and productivity in the Neuroscience research program of the City University of New York.
2008 Sue Rosenberg Zalk Travel & Research Fund received for the traveling and presenting at European C. elegans Meeting 2008 in Spain.
PRESENTATIONS
2005 Collin Ewald et al.: Expression, Purification and NMR Spectroscopy of T-Cadherin Domain1. Biozentrum Switzerland (Poster)
2006 Collin Ewald, Nancy Hynes, Joy Alcedo: Characterization of the Worm Homolog of memo, a Gene that Acts Downstream of the Mammalian EGF Pathway. European Worm Meeting. (Poster)
2007 Collin Ewald and Chris Li: Does targeted overexpression of APL-1 in neurons extend lifespan? International Worm Meeting. (Poster)
2008 Collin Ewald and Chris Li: The role of APL-1, an amyloid precursor-like protein in C. elegans. European Worm Meeting. (Poster)
2008 Collin Ewald and Chris Li: The role of APL-1, an amyloid precursor-like protein in C. elegans. Ninth Annual Celebration of Science, Engineering and Mathematics. Graduate Center of the City University of New York. (Poster)
2008 Collin Ewald and Chris Li: How worms can provide insights into Alzheimer's disease. The Graduate Student Symposium at The City College of New York. (Poster)
2008 Collin Ewald and Chris Li: How worms can provide insights into Alzheimer's disease. Doctoral Science Student Orientation at The Graduate Center of the City University of New York. (Poster)
2008 Collin Ewald and Chris Li: Lifespan Effects of APL-1, a C. elegans Protein Related to Human Amyloid Precusor Protein. 2008 C. elegans Neuronal Development, Synaptic Function, and Behavior Topic Meeting, University of Madison, USA. (Poster)
