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Anuradha Janakiraman

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Anuradha Janakiraman

Sharon D. Cosloy Associate Professor


Bacterial cellular organization, host-pathogen interactions

85 St Nicholas Terrace
The City College of CUNY

New York , NY 10031
Office Phone: (212) 650-8553


  1. Postdoc. Massachusetts General Hospital/Harvard Medical School, 2006
  2. Ph.D. in Microbiology, University of Illinois at Urbana-Champaign, 2001


Schumacher M, Huang KH, Zeng W, Janakiraman A (2017). Structure of the Z ring associated protein, ZapD, bound to the C-terminal domain of the tubulin-like protein, FtsZ, suggests mechanism of Z ring stabilization through FtsZ crosslinking. J. Biol. Chem. in press. doi: 10.1074/jbc.M116.773192.

Janakiraman A, Lesser CF (2017). How to manage stress: Lessons from an intracellular pathogen. Virulence in press. doi: 10.1080/21505594.2016.1256538

Buczek MS, Cardenas Arevalo AL, Janakiraman A (2016). ClpXP and ClpAP control the Escherichia coli division protein ZapC by proteolysis. Microbiol. 162:909-20.

Huang KH, Mychack A, Tchorzewski L, Janakiraman A (2016). Characterization of the FtsZ C-Terminal Variable (CTV) Region in Z-Ring Assembly and Interaction with the Z-Ring Stabilizer ZapD in E. coli Cytokinesis. PLoS One. 11:e0153337.

Schumacher MA, Zeng W, Huang KH, Tchorzewski L, Janakiraman A (2016). Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. J. Biol. Chem. 291:2485-98.

Janakiraman A (2016) The molecular role of the polar outer membrane protein IcsA (VirG) in Shigella actin-based motility. 2015. In Shigella: Molecular and Cellular Biology, Picking WD and Picking WL, editors, Caister Academic Press, Norwich, UK.

Huang KH, J. Durand-Heredia, A. Janakiraman. 2013. FtsZ-ring stability: of bundles, tubules, crosslinks and curves. J. Bacteriol. 195(9):1859-68.

Durand-Heredia J., E. Rivkin, G. Fan, J. Morales and A. Janakiraman. 2012. Identification of ZapD as a cell division factor that promotes the assembly of FtsZ in Escherichia coli. J. Bacteriol.,194(12):3189-98.

Fixen, K.R., A. Janakiraman, S.J. Garrity, D. J. Slade, A. N. Gray, N. Karahan, A. Hochschild, and M.B. Goldberg. 2012. Genetic reporter system for positioning of proteins at the bacterial pole. mBio v3(2):e00251-11.

Durand-Heredia J., H. H. Yu, S. De Carlo, C. F. Lesser, and A. Janakiraman. 2011. Identification and characterization of ZapC, a stabilizer of the FtsZ-ring in Escherichia coli. J. Bacteriol., 193(6): 1405-1413.

Janakiraman, A., K.R. Fixen, A.N. Gray, H. Niki and M.B. Goldberg. 2009. Genome-scale proteomic screen identifies role for DnaK in chaperoning of polar autotransporters in Shigella. J. Bacteriol., 191 (20):6300-6311

Nie L, Y. Ren, A. Janakiraman, S. Smith, and H.A. Schulz. 2008. A novel paradigm of fatty acid beta-oxidation exemplified by the thioesterase-dependent partial degradation of conjugated linoleic acid that fully supports growth of Escherichia coli. Biochemistry. 47(36):9618-26

Ikeda, J.*, A. Janakiraman*, D.G. Kehres, M.E. Maguire and J. M. Slauch. 2005. Transcriptional regulation of sitABCD of Salmonella enterica serovar Typhimurium by MntR and Fur. J. Bacteriol., 187 (3):912-922. * Co-first authors

Janakiraman, A. and M. B. Goldberg. 2004. Recent advances on the development of bacterial poles. Trends Microbiol., 12 (11): 518-525.

Janakiraman, A. and M.B. Goldberg. 2004. Evidence for polar positional information in E. coli independent of cell division and nucleoid occlusion. Proc. Natl. Acad. Sci., 101(3): 835-840.

Brandon, L.D., N. Goehring, A. Janakiraman, A.W. Yan, T. Wu, Beckwith J, and M.B. Goldberg. 2003. IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributed. Mol. Microbiol., 50(1): 45-60.

Kehres, D.G., A. Janakiraman, J.M. Slauch and M.E. Maguire. 2002. SitABCD is the alkaline Mn2+ transporter of Salmonella enterica serovar Typhimurium. J. Bacteriol., 184: 3159-66.

Kehres, D.G., A. Janakiraman, J.M. Slauch and M.E. Maguire. 2002. Regulation of Salmonella enterica serovar Typhimurium mntH transcription by H2O2, Fe2+, and Mn2+. J. Bacteriol., 184: 3151-58.

Ellermeier, C.D., A. Janakiraman, and J.M. Slauch. 2002. Construction of targeted single copy lac fusions using Lambda Red and FLP-mediated site-specific recombination in bacteria. Gene, 290: 153-61.

Janakiraman, A. and J.M. Slauch. 2000. The putative iron transport system SitABCD encoded on SPI1 is required for the full virulence of Salmonella typhimurium. Mol Microbiol., 35: 1147-57.