MR516 (office) | MR524 (lab)
Email: kali [ AT ] ccny [ DOT ] cuny [ DOT ] eduOffice Phone: (212) 650-8495
- Research Assistant Professor, Nutritional Sciences, Univ. of Kentucky, 2009-10
- Postdoctoral Fellow, Thomas Jefferson University, 2009
- Postdoctoral Fellow, University of Pennsylvania, 2007
- Ph.D. in Pharmacology, Yale University, 2002
- M.S. in Pharmacology, Yale University, 1998
- B.S. in Chemistry, California State University Northridge, 1996
Dr. Ali examines how apolipoproteins modulate blood cholesterol levels. High density lipoprotein (HDL) cholesterol levels are inversely correlated to the incidence of cardiovascular diseases. Apolipoprotein D (apoD) is a minor lipoprotein associated with HDL cholesterol. The Ali laboratory uses mice and cell culture studies to determine whether apoD plays a role in the formation of atherosclerotic plaques in blood vessels or modulation of plasma cholesterol levels by decreasing the levels of oxidative stress or inflammation in blood vessels.
Faleck D, Ali K, Roat R, Graham MJ, Crooke RM, Battisti R, Ahima RS, and Imai Y. Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets. Am J Physiol Endocrinol Metab. 2010 299 (2): E249-57. Epub 2010 May 18.
Ali K, Lund-Katz S, Lawson J, Phillips MC and Rader DJ. Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells. Atherosclerosis 2008; 196: 201-09.
Ali K, Middleton M, Puré E, and Rader DJ. Apolipoprotein E suppresses type 1 inflammatory response in vivo. Circ Res. 2005; 97 (9): 922-7.
Kothapalli D, Fuki I, Ali K, Stewart SA, Zhao L, Yahil R, Kwiatkowski D, Hawthorne EA, FitzGerald GA, Phillips MC, Lund-Katz S, Puré E, Rader DJ, Assoian RK. Antimitogenic effects of HDL and APOE mediated by Cox-2 dependent IP activation. J Clin Invest. 2004; 113: 609-18.