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Shubha Govind

Shubha Govind

Signal transduction in hematopoietic cancer and inflammation

Innate immunity and immune suppression mechanisms

Host parasite interactions, virus like particles

Biology Department
CCNY and CUNY Graduate Center
138th Street & Convent Avenue

New York , NY 10031
Email:
Office Phone: (212) 650-8476

Education:

  1. Postdoctoral training: Princeton University
  2. http://www.molbio.princeton.edu/
  3. PhD: University of Illinois, Urbana-Champaign
  4. http://mcb.illinois.edu/
  5. MS and BS: Miranda House & Delhi University, India
  6. http://www.mirandahouse.ac.in/
  7. http://www.du.ac.in/

Biography:

Honors and Awards

1975-1980 National Science Talent Scholar, NCERT, New Delhi, India
7/88-6/91 New Jersey Commission on Cancer Research Fellowship
7/97-6/2001 American Heart Association New Investigator Development Award
2006-2007 Excellence in Mentoring Award, CCNY
2013 President’s Award for Excellence

Research summary

Using the Drosophila model system, we are interested in understanding the mechanisms underlying hematopoietic cancer and inflammation. Our recent interest has focused on sumoylation, a conserved, post-translational protein modification mechanism in eukaryotes. Loss of sumoylation results in aberrant immune signaling, development of hematopoietic microtumors, and chronic inflammation. We are also actively engaged in identifying virulence factors produced by parasitic wasps that abrogate innate immune signaling and inflammation in Drosophila.

• Govind, S., Whalen, A.M. and Steward, R. (1992) In vivo self-association of the dorsal protein of Drosophila. Proc. Natl. Acad. Sci. USA 89:7861-7865.
• Govind, S., Brennan, L. and Steward, R. (1993) Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo. Development 117:135-148.
• Lemaitre, B., Meister, M., Govind, S., Georgel, P., Steward, R., Reichhart, J-M. and Hoffmann, J.A.[*] (1995) Functional analysis and regulation of nuclear import of dorsal during immune response of Drosophila. EMBO J. 14:536-545. [* 2011 Nobel Laureate]
• Govind, S., Drier, E., Huang, L. H. and Steward, R. (1996) The regulated nuclear import of the Drosophila Rel protein Dorsal: Structure-Function Analysis. Mol. Cell. Biol. 16:1103-1114.
• Govind, S. (1996) Rel signaling pathway and the melanotic tumor phenotype of Drosophila. Biochemical Society Transactions. 24:39-44.
• Qiu, P., Pan, P. and Govind, S. (1998) A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Development 125:1909-1920.
• Melk, J.P. and Govind, S. (1999) Developmental analysis of Ganaspis xanthopoda: A larval parasitoid of Drosophila. J. Exp. Biol. 202:1885-1896.
• Drier, E., Govind, S. and Steward, R. (2000) Cactus-independent regulation of Dorsal nuclear import by the ventral signal. Current Biology. 10:23-26.
• Sorrentino, R.P. Carton, Y. and Govind, S. (2002) Cellular immune response to parasite infection in the Drosophila lymph gland is developmentally regulated. Dev. Biol. 243 (1):65-80.
• Chiu, H. and Govind, S. (2002) Natural infection of D. melanogaster by virulent parasitic wasps induces apoptotic depletion of hematopoietic precursors. Cell Death and Differentiation 9:1379-1381.
• Sorrentino, R.P., Melk, J.P. and Govind, S. (2004) Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila. Genetics 166:1343-1356.
• Chiu, H., Ring, B., Sorrentino, R.P., Garza, D., Kalamarz, M. and Govind, S. (2005) Drosophila Ubc9 negatively regulates larval hematopoiesis and the antifungal peptide activation. Developmental Biology 288(1):60-72.
• Chiu, H., Morales, J., and Govind, S. (2006) Identification and immuno-localization of p40, a protein component of immune-suppressive virus-like particles from Leptopilina heterotoma, an obligate parasitoid wasp of Drosophila. Journal of General Virology 87:461-470.
• Schlenke, T.A., Morales, J., Govind, S., Clark, A.G. (2007) Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster. PLoS Pathogens 3(10):e158.
• Ferrarese, R., Morales, J., Fimiarz, D., Webb, B.A., and Govind, S. (2009) A supracellular system of actin-lined canals controls biogenesis and release of virulence factors in parasitoid venom glands. J. Exp. Biol. 212:2261-2268.
• Tsuyoshi, T., Sorrentino, R.P., Russell, M., Ferrarese, R., Govind, S., Schulz, R.A. (2009) Characterization of a lamellocyte transcriptional enhancer located within the misshapen gene of Drosophila melanogaster. PLoS One 4(7):e6429. Open Access.
• Paddibhatla I., Lee M.J., Kalamarz M.E., Ferrarese R., Govind S. (2010) Role for sumoylation in systemic inflammation and immune homeostasis in Drosophila larvae. PLoS Pathogens 6(12):e1001234. Open Access.
• Lee, M.J., Mondal, A., Small, C., Paddibhatla, I., Kawaguchi, A., Govind S. (2011) A database for the analysis of immunity genes in Drosophila: PADMA database. Fly 5(2):155-161.
• Gueguen, G., Rajwani, R., Paddibhatla, I., Morales, J. Govind, S. (2011) VLPs of Leptopilina boulardi share biogenesis and overall stellate morphology with VLPs of the heterotoma clade. Virus Research 160(1-2):159-65.
• Gokhman, V.E., Johnston, J.S., Small, C., Rajwani, R., Hanrahan, S.J., Govind, S. (2011) Genomic and karyotypic variation in Drosophila parasitoids (Hymenoptera: Cynipoidea: Figitidae) Comparative Cytogenetics Comparative Cytogenetics 5(3):211-221.
• Kalamarz, M.E., Paddibhatla, I., Nadar, C., Govind, S. (2012) Sumoylation is tumor-suppressive and confers proliferative quiescence to hematopoietic progenitors in Drosophila melanogaster larvae. Biology Open 1:161-172.
• Small, C., Paddibhatla, I., Rajwani, R., Govind, S. (2012) An introduction to parasitic wasps of Drosophila and the antiparasite immune response. Journal of Visualized Experiments. 63:e3347.
• Gueguen G., Bodunde O., Govind S. (2012) Association and effects of a new strain of Wolbachia on Leptopilina victoriae, a virulent parasitic wasp of Drosophila spp. Applied and Environmental Microbiology. 78(16):5962-5966.
• Heavner , M.E.; Gueguen, G., Rajwani, R., Small, C., Govind, S. (2013) Partial venom gland transcriptome of a Drosophila parasitic wasp, Leptopilina heterotoma, reveals novel and shared bioactive profiles among stinging Hymenoptera. Gene 526(2):195-204.
• Gueguen, G., Kalamarz, M.E., Uribe, J., Ramroop, J., Govind, S. (2013) Polydnaviral ankyrin proteins aid parasitic wasp survival by coordinate and selective inhibition of hematopoietic and immune NF-kappa B signaling in insect hosts. PLoS Pathogens 9(8): e1003580.
• Shaffer et al. Govind, S., Elgin, S.C.R. (83 authors) (2014) A course-based research experience: How benefits change with increased investment in instructional time. CBE Life Sci Educ. 13(1):111-30.
• Small, C., Ramroop, J., Otazo, M., Huang, L.H. Saleque, S., Govind, S. (2014) An unexpected link between Notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila. Genetics 197(2):471-483.
• Heavner, M.E., Hudgins, A.D., Rajwani, R., Morales, J., Govind, S. (2014) Harnessing the natural Drosophila-parasitoid model for integrating insect immunity with functional venomics. Current Opinion in Insect Science DOI: 10.1016/j.cois.2014.09.016.

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