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Hsin Wang Ph.D.

Hsin Wang, Ph.D.

NMR Research Associate

CDI-1.304
85 St Nicholas Terrace

New York , NY 10031
Email:
Office Phone: (212) 650-5831

Education:

  1. Ph.D. in Chemistry California Institute of Technology, Pasadena, CA USA 1987
  2. M.S. in Physical Chemistry National Taiwan University, Taipei, Taiwan, ROC 1979
  3. B.S. in Chemistry National Taiwan Normal University, Taipei, Taiwan, ROC 1973

Biography:

Research Interests
  • Structural Biology Research using nuclear magnetic resonance spectroscopy (NMR), including high-resolution solution state, high-resolution magic angle spinning (HRMAS) semi-solid state, and magic angle spinning (MAS) solid state studies.
Current Responsibilities
  • Managing an Agilent (Varian) DD2 600 MHz NMR spectrometers at the Center of Discovery and Innovation (CDI) at the City College of New York.  The instrument is equipped with 3 HXY narrow-bore solids probes for research in structural biology, polymer science, and materials science.
  • Collaborating with faculty members to guide students and research staffs in both solution and solid-states NMR research.  In addition to the Agilent (Varian) DD2 solid-state instrument we have access to solution-state instruments at the Advanced Science Research Center (ASRC) and at the nearby New York Structural Biology Center.
  • Postprocessing and analysis of NMR data with additional software such as NMRPIPE, NMRVIEW, and NUS (Non-Uniform Sampling).
Professional Experience
  • Dec, 2007 - Current: NMR Facility Manager, City College, City University of New York.
  • May, 1995 - Dec, 2007: NMR Facility Manager, College of Staten Island, City University of New York.
  • April, 1993 - Oct, 1994: Senior Research Investigator, Biophysics and Computational Chemistry (Protein NMR Research), Sterling Winthrop Pharmaceutical Research Division, Eastman Kodak Company, Collegeville, PA.
  • Sept., 1986 - April, 1993: Research Scientist and Senior Research Scientist, Therapeutic Center I (Protein NMR Research), Life Sciences Division, Eastman Kodak Company, Rochester, NY.
Recent Publications and Presentations
    1. Sebastien Alphonse, Shibani Bhattacharya, Hsin Wang, and Ranajeet Ghose, “Methyl Relaxation Measurements Reveal Patterns of Fast Dynamics in a Viral RNA-Directed RNA Polymerase”, Biochemistry, 2015, 54, 5828-38.
    2. Andrea Piserchio, Venkatesh Ramakrishnan, Hsin Wang, Tamer S. Kaoud, Boris Arshava, Kaushik Dutta, Kevin N. Dalby, and Ranajeet Ghose, “Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2”, Sci. Rep. 2015, 2, 11127.
    3. Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE, Ghose R, “Cystoviral Polymerase Complex Protein P7 Uses its Acidic C-terminal Tail Regulate the RNA-directed RNA Polymerase P2”, J Mol Biol. 2014, 426, 2580-93.
    4. Yah He, Rima Estephan, Xiaomin Yang, Adriana Vela, Hsin Wang, Cedric Bernard, and Ruth E. Stark “A Nuclear Magnetic Resonance-Based Structural Rationale for Contrasting Stiochiometry and Ligand Binding Site(s) in Fatty Acid-Binding Proteins”, Biochemistry, 2011, 50, 1283-95.
    5. Zhen Ren, Hsin Wang, and Ranajeet Ghose “Dynamics on Time-Scales in the Cystoviral RNA-directed RNA Polymerase”, Nucl. Acids Res. 2010, 38, 5105-5118.
    6. Junyan Zhong. Susana Frases, Hsin Wang, Arthuro Casadevall, and Ruth E. Stark  “Following Fungal Melanin Biosynthesis with Solid-State NMR: biopolymer molecular structures and connections to cell-wall polysaccharides”, Biochemistry 47, 4701-4710, 2008.
    7. Yan He, Xiaomin Yang, Hsin Wang, Rima Estephan, Fouad Francis, Sarala Kodukula, Judith Storch, and Ruth E. Stark “Solution-State Molceular Structure of Apo and Oleate-Liganded Liver Fatty Acid-Binding Protein”, Biochemistry 46, 12543-12556, 2007.
    8. Bingwu Yu, G. Vangadesan, Hsin Wang, Liana Jashi, Tatiana Yefremov,  Shiying Tian, Victor Gaba, Ilan Shomer, and Ruth E. Stark “Magic-Angle Spinning NMR Studies of Cell Wall-Bound Aromatic-Aliphatic Biopolyesters Associated with Strengthening of Intercellular Adhesion in Potato (Solarnum tuberosum L.) Tuber Parenchyma,” Biomacromolecules, 7, 937-944, 2006.
    9. Ramon Rosal, Paul Brandt-Rauf, Matthew R. Pincus, Hsin Wang, Yuehua Mao, Yin Li, and Robert L. Fine “The role f alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: necrosis versus apoptosis,” Advanced Drug Delivery Reviews 57, 653-660, 2005.
    10. Nithiananda Chatterjie, James P. Stables, Hsin Wang, and George J. Alexander “Anti-narcopletic Agent Modafinil and its Sulfone: a Novel Facile Synthesis and Potential Anti-Epileptic Activity,” Neurochem. Res., 29, 1481-1486, 2004.
    11. Ramon R. Rosal, Matthew R. Pincus,  Paul W. Brandt-Rauf, Robert L. Fine, and Hsin Wang “NMR Solution Structure of a Peptide from the mdm-2 Binding Domain of the p53 Protein that is Selectively Cytotoxic to Cancer Cells,” Biochemistry, 43, 1854-1861, 2004.
    12. Hsin Wang “Simultaneous NOE Experiments,” Talk at The New York Structural Biology Metagroup Discussion, December 17, 2003.
    13. W. Xu, Q. Luo, H. Wang, L.C. Francesconi, R.E. Stark and D.L. Akins “A polyoxoanion occluded within modified MCM-41: spectroscopy and structure,” J. Phys. Chem. B., 107, 497-501, 2003.
    14. Hsin Wang, Yan He, Christopher D. Kroenke, Sarala Kodukula, Judith Storch, Arthur G. Palmer, and Ruth E. Stark “Titration and Exchange Studies of Liver Fatty Acid-Binding Protein with 13C-Labeled Long-Chain Fatty Acids,” Biochemistry 41, 5453-5461, 2002.
    15. N. Chatterjie, G. Alexander, and H. Wang “Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests”,  Neurochem. Res. 26, 1171-1176, 2001.
    16. Xiuhua Fang, Feng Qiu, Bin Yan, Hsin Wang, Andrew Mort, and Ruth E. Stark “NMR Studies of Molecular Structure in Fruit Cuticle Polyesters,”  Phytochemistry, 57, 1035-1042, 2001.
    17. Hsin Wang, Xiaomin Yang, Dmitry Volfson, Peter Liu, Sarala Kodukula, Judith Storch, and Ruth E. Stark “Unusual Porphyrin and Heme Ligands for Liver Fatty Acid-Binding Protein” Keystone Symposium on Molecular and Cellular Biology:  Frontiers of NMR in Molecular Biology-VII, P231, 2001.
    18. Wen-feng Yu, Chang-Shung Tung, Hsin Wang, and Maria Luisa Tasayco “NMR Analysis of Cleaved Escherichia coli Thioredoxin (1-73/74-108) and its P76A Variant: Cis/trans Peptide Isomerization,” Protein Science 9, 20-28, 2000.
    19. Hsin Wang, Xiaomin Yang,  Yan He, and Ruth E. Stark “Swimming in the Protein Aromatic Alphabet Soup,” Talk at the Varian NMR User’s meeting, April 6, 2000.
    20. Hsin Wang, Yan He, Christopher D. Kroenke, Sarala Kodukula, Judith Storch, Arthur G. Palmer, and Ruth E. Stark   “Rat Liver Fatty Acid-Binding Protein: Exchange Rates for Associated Oleic Acid Molecules and Backbone Dynamics of the Lipid Portal Regions,”   The 41st Experimental NMR Conference, W/TH PA-051,  April 9-14, 2000.
    21. Yan He, Hsin Wang, Ghayath Elias, Kuo Tung Hsu, Judith Storch, and Ruth E. Stark “Titration of 15N-LFABP with Oleate Augments Information on Protein-Fatty Acid Derived from Other Physical Methods,” Keystone Symposium on Molecular and Cellular Biology:  Frontiers of NMR in Molecular Biology-VI, P316, 1999.
    22. Hsin Wang, Yan He, Kuo Tung Hsu, Joseph  F. Magliocca, Judith Storch, and Ruth  E. Stark “ 1H, 15N, 13C Resonance Assignments and Secondary Structure of Liver Fatty Acid-Binding Protein,”  J. Biomol. NMR , 12, 197-199, 1998.

      Personal Interests
      • Singing: Currently sing with Friday Night Renaissance Sight-Reading Group and New Amsterdam Singers in New York.  Previously sang with Blue Hill Troupe, New York Revels, New Jersey State Opera Chorus, Richmond Choral Society, and Monmouth Civic Chorus.  Sang in operas including Turandot, il Trovatore, Lucia di Lammermoore, Cavalleria Rusticana, Pagliacci, and Princess Ida.
      • Hiking: Have been a member of Adirondack Mountain Club since 1987; Am an Adirondacks Forty-Sixer and climbed all 46 above 4000 ft peaks in Adirondacks, about 1/3 in winter backpacking trips.
      • Travel.