New York , NY 10031
We study the structure and dynamics of cell signaling proteins. These proteins function as molecular switches, which can fail to work properly for various reasons, causing diseases such as cancer and cystic fibrosis. We use small angle X-ray and neutron scattering and other structural methods, as well as biochemical and cell biological experiments to study these proteins and their interactions.
In addition, we develop and apply methods of quasielastic neutron scattering, particularly neutron spin echo spectroscopy, to study nanoscale protein dynamics and motion.
Keywords: biophysics; biochemistry; cell signaling; signal transduction; protein structure; protein dynamics; protein motion; protein-protein interaction; X-ray scattering; neutron scattering; quasielastic neutron scattering; neutron spin echo spectroscopy.